![]() PLoS ONE 9(6):Įditor: Lise Lotte Gluud, Copenhagen University Hospital Gentofte, Denmark (2014) Effects of Prophylactic and Therapeutic Paracetamol Treatment during Vaccination on Hepatitis B Antibody Levels in Adults: Two Open-Label, Randomized Controlled Trials. These findings prompt to consider therapeutic instead of prophylactic treatment to ensure maximal vaccination efficacy and retain the possibility to treat pain and fever after vaccination.Ĭitation: Doedée AMCM, Boland GJ, Pennings JLA, de Klerk A, Berbers GAM, van der Klis FRM, et al. Only prophylactic paracetamol treatment, and not therapeutic treatment, during vaccination has a negative influence on the antibody concentration after hepatitis B vaccination in adults. The anti-HBs level in the therapeutic paracetamol group (4958 mIU/mL) was not different (p = 0.34) from the level in the control group. One month after the second booster vaccination, the anti-HBs level in the prophylactic paracetamol group was significantly lower (p = 0.048) than the level in the control group (4257 mIU/mL vs. Anti-HBs levels were measured prior to and one month after the second booster vaccination on ADVIA Centaur XP. None of the participants used paracetamol around the second booster (6 months) vaccination. The control group received no paracetamol. The study groups received paracetamol for 24 hours starting at the time of (prophylactic use) - or 6 hours after (therapeutic use) the primary (0 month) and first booster (1 month) hepatitis B vaccination. In two randomized, controlled, open-label studies 496 healthy young adults were randomly assigned to three groups. ![]() In addition, the effect of timing of paracetamol intake was investigated. The goal of this study was to establish whether paracetamol exerts similar effects in young adults. Recently published results indicate that paracetamol inhibits the vaccination response in infants when given prior to vaccination. Worldwide, paracetamol is administered as a remedy for complaints that occur after vaccination.
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